MBBS, FRCPath, D Phil (Oxon), FHKAM (Path), FRCP, FRS
Tam Wah-Ching Professorship in Medical Science and Chair of Virology
Division of Public Health Laboratory Sciences
Professor Malik Peiris is a clinical and public health virologist with a particular interest in emerging virus disease at the animal-human interface using a “One Health” approach, including influenza, coronaviruses (SARS, MERS) and others. His current research encompasses the pathogenesis, innate immune responses, transmission, ecology and epidemiology of human and animal (poultry, swine, wild birds) influenza viruses. His research has provided understanding on the emergence and pathogenesis of the 2009 pandemic H1N1 virus and on avian influenza viruses H5N1, H9N2 and H7N9. His collaborative research has provided evidence-based options for the control of these viruses in poultry and in humans. In 2003, he played a key role in the discovery that a novel coronavirus was the cause of SARS, its diagnosis and pathogenesis. Currently he is researching the recently emerged MERS coronavirus.
He coordinates a 5 year multi-disciplinary and multi-institutional Theme Based Research grant on “Influenza Transmission and Pathogenesis” from the Research Grants Council, Hong Kong. He is an investigator in the Centers of Excellence for Influenza Research and Surveillance (CEIRS) program of NIAID, National Institutes of Health, USA. He has an extensive collaborative research network globally.
He co-directs the WHO H5 Reference Laboratory at HKU and serves on many standing committees and ad-hoc advisory committees of the WHO and FAO.
He was elected a Fellow of the Royal Society of London in 2006, Fellow of the American Academy of Microbiology in 2016 and Foreign Associate of National Academy of Sciences in 2017. He was awarded the Officier de la Legion d’Honneur, France (2017), Mahathir Science Award, Akademi Sains, Malaysia (2007) and Silver Bauhinia Star (S.B.S.), Hong Kong SAR (2008). He serves on the editorial boards of Lancet Infectious Diseases and Current Opinion in Virology.
Chu DKW, Hui KPY, Perera RAPM, Miguel E, Niemeyer D, Zhao J, Channappanavar R, Dudas G, Oladipo JO, Traoré A, Fassi-Fihri O, Ali A, Demissié GF, Muth D, Chan MCW, Nicholls JM, Meyerholz DK, Kuranga SA, Mamo G, Zhou Z, So RTY, Hemida MG, Webby RJ, Roger F, Rambaut A, Poon LLM, Perlman S, Drosten C, Chevalier V, Peiris M. MERS coronaviruses from camels in Africa exhibit region-dependent genetic diversity. Proc Natl Acad Sci U S A. 2018; 115: 3144-3149. (Impact factor 9.7)
Chan MC, Kuok DI, Leung CY, Hui KP, Valkenburg SA, Lau EH, Nicholls JM, Fang X, Guan Y, Lee JW, Chan RW, Webster RG, Matthay MA, Peiris JSM*. Human mesenchymal stromal cells reduce influenza A H5N1-associated acute lung injury in vitro and in vivo. Proc Natl Acad Sci U S A. 2016;113:3621-6. (Impact Factor 9.7; citations 16).
Chan RW, Hemida MG, Kayali G, Chu DK, Poon LL, Alnaeem A, Ali MA, Tao KP, Ng HY, Chan MC, Guan Y, Nicholls JM, Peiris JSM*. Tropism and replication of Middle East respiratory syndrome coronavirus from dromedary camels in the human respiratory tract: an in-vitro and ex-vivo study. Lancet Respir Med. 2014;2:813-22. (Impact factor 19.3; citations 31)
Cowling BJ, Chan KH, Fang VJ, Lau LLH, So THC, Fung ROP Ma ESK, Kwong ASK Chan CW, Tsui WWS, Ngai HY, Chu DWS, Lee PWY, Chiu MC, Leung GM, Peiris JSM. Comparative Epidemiology of Pandemic and Seasonal Influenza A in Households. New Engl J Med 2010; 363: 2175-84. (Impact factor 72.4; citations 212)
Vijaykrishna D, Poon LLM, Zhu HC, Ma SK, Li OTW, Cheung CL, Smith GLD,Peiris JSM*, Guan Y*. Reassortment of pandemic H1N1/2009 influenza A virus in swine. Science 2010; 328: 1529 (Impact factor 37.2; citations 229)
Nicholls JM, Chan MC, Chan WY, Wong HK, Cheung CY, Kwong DL, Wong MP, Chui WH, Poon LL, Tsao SW, Guan Y, Peiris JSM*. Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract. Nat Med. 2007; 13: 147-9 (Impact factor 29.9; citations 230)
Peiris JSM*, Lai ST, Poon LL, Guan Y, Yam LY, Lim W, Nicholls J, Yee WK, Yan WW, Cheung MT, Cheng VC, Chan KH, Tsang DN, Yung RW, Ng TK, Yuen KY. Coronavirus as a possible cause of severe acute respiratory syndrome. Lancet. 2003 361:1319-25 (Impact factor 47.8; citations 1377)
Peiris JSM, Chu CM, Cheng VCC, Chan KS, Hung IFN, Poon LLM, Law KI, Tang BSF, Hon TYW, Chan CS, Chan KH, Ng JSC, Zheng BJ, Ng WL, Lai RWM, Guan Y, Yuen KY. Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study. Lancet. 2003; 361: 1767-72. (Impact factor 47.8; citations 808)
Cheung CY, Poon LL, Lau AS, Luk W, Lau YL, Shortridge KF, Gordon S, Guan Y, Peiris JSM*. Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1) viruses: a mechanism for the unusual severity of human disease? Lancet. 2002; 360: 1831-7 (Impact factor 47.8; citations 560)