MBBS, FRCPath, D Phil (Oxon), FHKAM (Path), FRCP, FRS
Tam Wah-Ching Professorship in Medical Science
Division of Public Health Laboratory Sciences
Professor Malik Peiris is a clinical and public health virologist with a particular interest in emerging virus disease at the animal-human interface including influenza, coronaviruses (SARS, MERS) and others. His current research encompasses the pathogenesis, innate immune responses, transmission, ecology and epidemiology of human and animal (poultry, swine, wild birds) influenza viruses. His research has provided understanding on the emergence and pathogenesis of the 2009 pandemic H1N1 virus and on avian influenza viruses H5N1, H9N2 and H7N9. His collaborative research has provided evidence-based options for the control of these viruses in poultry and in humans. In 2003, he played a key role in the discovery that a novel coronavirus was the cause of SARS, its diagnosis and pathogenesis. Currently he is researching the recently emerged MERS coronavirus.
He coordinates an 8 year multi-disciplinary and multi-institutional Area of Excellence Program of the University Grants Committee of Hong Kong on the “Control of Pandemic and Inter-pandemic Influenza” and a recent Theme Based Research grant on “Influenza Transmission and Pathogenesis” from the Research Grants Council, Hong Kong. He is an investigator in the Centers of Excellence for Influenza Research and Surveillance (CEIRS) program of NIAID, National Institutes of Health, USA. He has an extensive collaborative research network globally.
He co-directs the WHO H5 Reference Laboratory at HKU and serves on many standing committees and ad-hoc advisory committees of the WHO and FAO.
He was elected a Fellow of the Royal Society of London in 2006, awarded the Chevalier de la Legion d’Honneur, France (2007), Mahathir Science Award, AkademiSains, Malaysia (2007) and Silver Bauhinia Star (S.B.S.), Hong Kong SAR (2008). He serves on the editorial boards of Lancet Infectious Diseases and PLoS Medicine.
Chan MC, Kuok DI, Leung CY, Hui KP, Valkenburg SA, Lau EH, Nicholls JM, Fang X, Guan Y, Lee JW, Chan RW, Webster RG, Matthay MA, Peiris JSM*. Human mesenchymal stromal cells reduce influenza A H5N1-associated acute lung injury in vitro and in vivo. Proc Natl Acad Sci U S A. 2016;113:3621-6. (Impact Factor 9.4).
Chan RW, Hemida MG, Kayali G, Chu DK, Poon LL, Alnaeem A, Ali MA, Tao KP, Ng HY, Chan MC, Guan Y, Nicholls JM, Peiris JSM*. Tropism and replication of Middle East respiratory syndrome coronavirus from dromedary camels in the human respiratory tract: an in-vitro and ex-vivo study. Lancet Respir Med. 2014;2:813-22. (Impact factor 15.3; citations 20)
Wu JT, Ho A, Ma ES, Lee CK, Chu DK, Ho PL, Hung IF, Ho LM, Lin CK, Tsang T, Lo SV, Lau YL, Leung GM, Cowling BJ, Peiris JSM. Estimating infection attack rates and severity in real time during an influenza pandemic: analysis of serial cross-sectional serologic surveillance data. PLoS Med. 2011 Oct;8(10):e1001103. (Impact Factor 13.6; citations 32).
Cowling BJ, Chan KH, Fang VJ, Lau LLH, So THC, Fung ROP Ma ESK, Kwong ASK Chan CW, Tsui WWS, Ngai HY, Chu DWS, Lee PWY, Chiu MC, Leung GM, Peiris JSM. Comparative Epidemiology of Pandemic and Seasonal Influenza A in Households. New Engl J Med 2010; 363: 2175-84. (Impact factor 51.7; citations 201)
Vijaykrishna D, Poon LLM, Zhu HC, Ma SK, Li OTW, Cheung CL, Smith GLD,Peiris JSM*, Guan Y*. Reassortment of pandemic H1N1/2009 influenza A virus in swine. Science 2010; 328: 1529 (Impact factor 31.0; citations 207)
Nicholls JM, Chan MC, Chan WY, Wong HK, Cheung CY, Kwong DL, Wong MP, Chui WH, Poon LL, Tsao SW, Guan Y, Peiris JSM*. Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract. Nat Med. 2007; 13: 147-9 (Impact factor 22.9; citations 213)
Peiris JSM*, Lai ST, Poon LL, Guan Y, Yam LY, Lim W, Nicholls J, Yee WK, Yan WW, Cheung MT, Cheng VC, Chan KH, Tsang DN, Yung RW, Ng TK, Yuen KY. Coronavirus as a possible cause of severe acute respiratory syndrome. Lancet. 2003 361:1319-25 (Impact factor 39.1; citations 1329)
Peiris JSM, Chu CM, Cheng VCC, Chan KS, Hung IFN, Poon LLM, Law KI, Tang BSF, Hon TYW, Chan CS, Chan KH, Ng JSC, Zheng BJ, Ng WL, Lai RWM, Guan Y, Yuen KY. Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study. Lancet. 2003; 361: 1767-72. (Impact factor 39.1; citations 784)
Cheung CY, Poon LL, Lau AS, Luk W, Lau YL, Shortridge KF, Gordon S, Guan Y, Peiris JSM*. Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1) viruses: a mechanism for the unusual severity of human disease? Lancet. 2002; 360: 1831-7 (Impact factor 39.1; citations 527)