Poon, Lit Man Leo

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BSc(HKBU), MPhil(CUHK), DPhil(Oxon)
 
Associate Professor and Division Head
Division of Public Health Laboratory Sciences
 
Contact Information
Tel: 3917 9943
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Biography

Dr Leo Poon received his doctoral training in Sir William Dunn School of Pathology in University of Oxford (1996-1999). After his graduation, he returned to Hong Kong and worked as a postdoctoral fellow in the Chinese University of Hong Kong (1999-2001). He joined The University of Hong Kong in 2001. Dr Poon has strong interests that are related to emerging viruses, ranging from studying basic biology of RNA viruses to developing molecular diagnostic tools for infectious diseases. His work primarily focuses on influenza virus and coronavirus. He has over 150 peer-reviewed publications, and he is an ISI top 1 % most cited scientist (Total number of citations: 13883; H-index: 58). 

In 2003, Dr Poon involved in the discovery of a novel coronavirus as the aetiological cause of SARS. He is one of the firsts who decoded the first SARS coronavirus sequence. These findings allowed him to develop several useful molecular tests for the diagnosis of SARS. The identification of SARS coronavirus in humans and animals also prompted him to hunt for novel viruses in wildlife and this leaded to the discovery of the first and many others coronaviruses in bats. 
 
Dr Poon involves in influenza research for over 18 years. He studied the replication and pathogenesis of this virus. He developed several molecular tests for emerging avian influenza viruses (e.g. H5N1, pandemic H1N1/2009 and H7N9). In 2009, he played an active role in the H1N1 pandemic and identified the first reassortant of pandemic H1N1/2009 virus in pigs. Currently, he focuses on researching the viral replication and vaccinology of influenza virus.
 
Dr Poon serves as a virology expert in several international organizations. He is a committee member in the Coronavirus Study Group under the International Committee on Taxonomy of Viruses (2006-now) and he is also an expert in the Influenza Molecular Diagnosis Working Group, World Health Organization (2009-now). He previously served as an ad hoc consultant in the Food and Agriculture Organization of the United Nations (2013-2014) and in the World Organization for Animal Health (2014) for MERS. He is an editor in PLoS One (2010-now) and Virus Evolution (2014-now). He also regularly serves as a reviewer in many top tier journals. 
 
Dr Poon has received fund as a PI from various research organizations, including NIAID (USA), European Commission (EU), HMRF (Hong Kong), GRF (Hong Kong) and Area of Excellence Scheme (Hong Kong).  He has trained 11 postgraduate research students, with one received a Butterfield-Croucher Studentship and one received an Outstanding Research Postgraduate Student Award.
 

 

 

Selected Publications (Pub Med Search)

  1. Valkenburg SA, Li OT, Mak PW, Mok CK, Nicholls JM, Guan Y, Waldmann TA, PeirisJS, Perera LP, Poon LL. IL-15 adjuvanted multivalent vaccinia-based universalinfluenza vaccine requires CD4+ T cells for heterosubtypic protection. Proc Natl Acad Sci U S A. 111:5676-81. [Impact factor: 9.8 (Quartile 1 in Category); number of citation: 0]
  2. Wong CK, Zhu H, Li OT, Leung YH, Chan MC, Guan Y, Peiris JS, Poon LL.Molecular detection of human H7N9 influenza A virus causing outbreaks in China. Clin Chem. 2013 59:1062-7.[Impact factor: 7.8 (Quartile 1 in Category); number of citation: 6]
  3. Ekiert DC, Friesen RH, Bhabha G, Kwaks T, Jongeneelen M, Yu W, Ophorst C, Cox F, Korse HJ, Brandenburg B, Vogels R, Brakenhoff JP, Kompier R, Koldijk MH, Cornelissen LA, Poon LL, Peiris M, Koudstaal W, Wilson IA, Goudsmit J. 2011. A Highly Conserved Neutralizing Epitope on Group 2 Influenza A Viruses. Science. 333:843-50.[Impact factor: 31.5 (Quartile 1 in Category); number of citation: 208]
  4. Vijaykrishna D*, Poon LL*, Zhu HC, Ma SK, Li OTW, Cheung CL, Smith GJD, Peiris JSM, Guan Y. 2010. Reassortment of pandemic H1N1/2009 influenza A virus in swine. Science. 328:1529. [* Co-first authors; [Impact factor: 31.5 (Quartile 1 in Category); number of citation: 170]
  5. Poon LL, Mak PW, Li OT, Chan KH, Cheung CL, Ma ES, Yen HL, Vijaykrishna D, Guan Y, Peiris JS. Rapid Detection of Reassortment of Pandemic H1N1/2009 Influenza Virus. 2010. Clin Chem. 56:1340-4.[Impact factor: 7.8 (Quartile 1 in Category); number of citation: 19]
  6. Poon LL, Chan KH, Smith GJ, Leung CS, Guan Y, Yuen KY, Peiris JS. 2009. Molecular Detection of a Novel Human Influenza (H1N1) of Pandemic Potential by Conventional and Real-Time Quantitative RT-PCR Assays. Clin Chem. 55:1555-8.[Impact factor: 7.8 Quartile 1 in Category); number of citation: 89]
  7. Poon LL, Wong BW, Ma EH, Chan KH, Chow LM, Abeyewickreme W, Tangpukdee N, Yuen KY, Guan Y, Looareesuwan S, and Peiris JS. 2006. A sensitive and inexpensive molecular test for falciparum malaria: detecting Plasmodium falciparum DNA directly from heat-treated blood by loop-mediated isothermal amplification. Clin Chem. 52:303-6.[Impact factor: 7.8(Quartile 1 in Category); number of citation: 179]
  8. Poon LL, Chu DK, Chan KH, Wong OK, Ellis TM, Leung YH, Lau SK, Woo PC, Suen KY, Yuen KY, Guan Y, Peiris JS. 2005. Identification of a novel coronavirus in bats. J Virol.79:2001-2009.[ Impact factor: 5.08 (Quartile 1 in Category); number of citation: 163 ]
  9. Guan Y, Zheng BJ, He YQ, Liu XL, Zhuang ZX, Cheung CL, Luo SW, Li PH, Zhang LJ, Guan YL, Butt KM, Wong KL, Chan KW, Lim W, Shortridge KF, Yuen KY, Peiris JSM, Poon LLM. 2003. Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China. Science. 302:276-278. [Impact factor: 31.5 (Quartile 1 in Category); number of citation: 803]
  10. Peiris JS, Lai ST, Poon LL, Guan Y, Yam LYC, Lim W, et al. 2003. Coronavirus as a possible cause of severe acute respiratory syndrome. Lancet. 361(9366):1319-1325.[Impact factor:39.2 (Quartile 1 in Category); number of citation: 1489]

 

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