Wu, Tsz Kei Joseph

Associate Professor
Division of Epidemiology and Biostatistics
Contact Information
Tel: 3917 6709
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Joseph Wu leads the infectious disease modeling research in the HKU School of Public Health. His primary research is in influenza epidemiology and control with a focus on pandemic preparedness and response. He earned his PhD in Operations Research from MIT in 2003 and BS in Chemical Engineering from MIT in 1999. His work primarily entails developing mathematical models to assess the potential benefits and resource requirement of mitigation and surveillance strategies for communicable diseases including influenza, hand-foot-and-mouth disease, HPV infection and yellow fever. Since 2013, he has been working closely with the China CDC on the risk assessment and management of avian influenza A/H7N9 epidemics and health economic evaluation of vaccination against hand-foot-and-mouth disease in China.

He is the producer of HKU's first Massive Open Online Courseware (MOOC) Epidemics which has had more than 16,000 people enrolled since its first launch on the edX platform in 2014. He is the director of the Croucher Summer Course Vaccinology for Public Health and Clinical Practice.

He is an affiliated faculty member of the Center for Communicable Diseases Dynamics (CCDD) at the Harvard School of Public Health. He is an associate editor of the American Journal of Epidemiology and a Fellow of the UK’s Faculty of Public Health. He is a member of the Technical Working Group for the WHO Public Health Research Agenda for Influenza. He is a member of the Scientific Committee for the Center for Health Protection in Hong Kong. He was a recipient of Outstanding Young Researcher Award from HKU in 2015.


Selected Publications (Pub Med Search)

  1. Leung K, Lipsitch M, Yuen KY, Wu JT. Monitoring the fitness of antiviral-resistant influenza strains during an epidemic: a mathematical modelling study. The Lancet Infectious Diseases, 17(3): 339-347 (2017).
  2. Wu JT, Peak C, Leung GM & Lipsitch M. Fractional Dosing of Yellow Fever Vaccine to Extend Supply: A Modeling Study. The Lancet. doi: 10.1016/S0140-6736(16)31838-4 (2016).
  3. Wu JT, Jit, M, Zheng, Y, Leung, K, Xing, W, Yang, J, Liao, Q, Cowling, BJ, Yang, B, Lau, EH, Takahashi, S, Farrar, JJ, Grenfell, BT, Leung, GM & Yu, H. Routine Pediatric Enterovirus 71 Vaccination in China: a Cost-Effectiveness Analysis. PLoS Medicine 13, e1001975, doi:10.1371/journal.pmed.1001975 (2016).
  4. Wu JT, Leung, K, Perera, RA, Chu, DK, Lee, CK, Hung, IF, Lin, CK, Lo, SV, Lau, YL, Leung, GM, Cowling, BJ & Peiris, JS. Inferring influenza infection attack rate from seroprevalence data. PLoS Pathogens 10, e1004054, doi:10.1371/journal.ppat.1004054 (2014).
  5. Yu H*, Wu JT*, Cowling BJ, Liao Q, Fang VJ, Zhou S, Wu P, Zhou H, Lau EHY, Guo D, Ni MY, Peng Z, Feng L, Jiang H, Luo H, Li Q, Feng Z, Wang Y, Yang W & Leung GM. Effect of closure of live poultry markets on poultry-to-person transmission of avian influenza A H7N9 virus: an ecological study. The Lancet 383, 541-548, doi:10.1016/S0140-6736(13)61904-2 (2014).
  6. Wu JT, Ho, A, Ma, ES, Lee, CK, Chu, DK, Ho, PL, Hung, IF, Ho, LM, Lin, CK, Tsang, T, Lo, SV, Lau, YL, Leung, GM, Cowling, BJ & Peiris, JS. Estimating Infection Attack Rates and Severity in Real Time during an Influenza Pandemic: Analysis of Serial Cross-Sectional Serologic Surveillance Data. PLoS Medicine 8, e1001103, doi:10.1371/journal.pmed.1001103 (2011).
  7. Wu JT, Cowling, BJ, Lau, EH, Ip, DK, Ho, LM, Tsang, T, Chuang, SK, Leung, PY, Lo, SV, Liu, SH & Riley, S. School closure and mitigation of pandemic (H1N1) 2009, Hong Kong. Emerging Infectious Diseases 16, 538-541 (2010).
  8. Wu JT, Lee, CK, Cowling, BJ & Yuen, KY. Logistical feasibility and potential benefits of a population-wide passive-immunotherapy program during an influenza pandemic. Proceedings of the National Academy of Sciences of the United States of America 107, 3269-3274, doi:10.1073/pnas.0911596107 (2010).
  9. Wu JT, Ma, ES, Lee, CK, Chu, DK, Ho, PL, Shen, AL, Ho, A, Hung, IF, Riley, S, Ho, LM, Lin, CK, Tsang, T, Lo, SV, Lau, YL, Leung, GM, Cowling, BJ & Malik Peiris, JS. The infection attack rate and severity of 2009 pandemic H1N1 influenza in Hong Kong. Clinical Infectious Diseases 51, 1184-1191, doi:10.1086/656740 (2010).
  10. Wu JT, Leung, GM, Lipsitch, M, Cooper, BS & Riley, S. Hedging against antiviral resistance during the next influenza pandemic using small stockpiles of an alternative chemotherapy. PLoS Medicine 6, e1000085, doi:10.1371/journal.pmed.1000085 (2009).
  11. Wu JT, Riley, S, Fraser, C & Leung, GM. Reducing the impact of the next influenza pandemic using household-based public health interventions. PLoS Medicine 3, e361, doi:10.1371/journal.pmed.0030361 (2006).


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