Dr. Hui-Ling Yen received her Ph.D. in Epidemiological Science in 2005 from The University of Michigan, Ann Arbor followed by her postdoctoral training at St. Jude Children’s Research Hospital, Memphis, TN. Her research interests focus on understanding the mechanism facilitating the transmission of influenza A virus among and between different reservoirs, exploring the potential virus-host interactions that affect viral pathogenicity and the host clinical outcome, and examining the molecular determinants that confer antiviral resistance.
The ongoing research projects aim to study the modes of influenza transmission in animal models and at the animal-human interface. We continue to study the functionality of viral proteins associated with transmissibility and pathogenicity. Those studies are in collaboration with researchers from the University of Hong Kong (Hong Kong), Guangdong Provincial CDC (China), Genomic Research Centre, Academia Sinica (Taiwan), and St. Jude Children’s Research Hospital (USA).
Dr. Yen is a Full Member of the American Society of Virology. She serves as an Editorial Board Member at Antiviral Research and an Academic Editor at PLoS ONE.
Cheung, P.P.H., S.J. Watson, K.-T. Choy, S.F. Sia, D.D.Y. Wong, L.L.M. Poon, P. Kellam, Y. Guan, J.S.M. Peiris, H.-L. Yen. 2014. Generation and characterization of influenza A viruses with altered polymerase fidelity. Nat Commun.5: 4794. PubMed PMID: 25183443
Yen, H.-L., J. L. McKimm-Breschkin, K.-T. Choy, D.D. Wong, P.P. Cheung, J. Zhou, I.H. Ng, H. Zhu, R.J. Webby, Y. Guan, R.G. Webster, J.S.M. Peiris. 2013. Resistance to neuraminidase inhibitors conferred by an R292K mutation in a human influenza virus H7N9 isolate can be masked by a mixed R/K viral population. mBio 4(4). pii: e00396-13.
Hu, Y., S. Lu, Z. Song, W. Wang, P. Hao, J. Li, X. Zhang, H.-L. Yen, B. Shi, T. Li, W. Guan, L. Xu, Y. Liu, S. Wang, X. Zhang, D. Tian, Z. Zhu, J. He, K. Huang, H. Chen, L. Zheng, X. Li, J. Ping, B. Kang, X. Xi, L. Zha, Y. Li, Z. Zhang, M. Peiris, Z. Yuan. 2013. Association between adverse clinical outcome in human disease caused by novel influenza A H7N9 virus and sustained viral shedding and emergence of antiviral resistance. Lancet 381:2273-9.
Wong, D.D.Y., K.-T. Choy, R.W.Y. Chan, S.F. Sia, H.-P. Chiu, P.P.H. Cheung, M.C.W. Chan, J.S.M. Peiris, and H.-L. Yen. 2012. Comparable fitness and transmissibility between oseltamivir-resistant pandemic 2009 and seasonal H1N1 influenza viruses with the H275Y neuraminidase mutation. J. Virol. 86: 10558–10570.
Yen, H. L., C.-H. Liang, C.-Y. Wu, H. L. Forrest, A. Ferguson, K.-T. Choy, J. Jones, D. D.-Y. Wong, P. P.-H. Cheung, C.-H. Hsu, O. T. Li, K. M. Yuen, R. W. Y. Chan, L. L. M. Poon, M. C. W. Chan, J. M. Nicholls, S. Krauss, C.-H. Wong, Y. Guan, R. G. Webster, R. J. Webby, and J. S. M. Peiris. 2011. Hemagglutinin–neuraminidase balance confers respiratory-droplet transmissibility of the pandemic H1N1 influenza virus in ferrets. Proc. Natl. Acad. Sci. U.S.A. 108:14264-14269.
Yen, H. L., J. R. Aldridge, A. C. Boon, N. A. Ilyushina, R. Salomon, D. J. Hulse-Post, H. Marjuki, J. Franks, D. A. Boltz, D. Bush, A. S. Lipatov, R. J. Webby, J. E. Rehg, R. G. Webster. 2009. Changes in H5N1 influenza virus hemagglutinin receptor binding domain affect systemic spread. Proc. Natl. Acad. Sci. U.S.A. 106: 286-291.
Yen, H. L., N. A. Ilyushina, R. Salomon, E. Hoffmann, R. G. Webster, E. A. Govorkova. 2007. Neuraminidase inhibitor–resistant recombinant A/Vietnam/1203/04 (H5N1) influenza viruses retain their replication efficiency and pathogenicity in vitro and in vivo. J. Virol. 81: 12418-12426.
Yen, H. L., A. S. Lipatov, N. A. Ilyushina, E. A.Govrokova, J. Franks, N. Yilmaz, A.. Douglas, A. Hay, S. Krauss, J. E. Rehg, E. Hoffmann, R. G. Webster.2007. Inefficiant transmission of H5N1 Influenza Viruses in a Ferret Contact Model. J. Virol. 81: 6890-6898.
Yen, H. L., M. L. Herlocher, E. Hoffmann, M. N. Matrosovich, A. S. Monto, R. G. Webster, E. A. Govorkova. 2005. Neuraminidase inhibitor-resistant influenza viruses may differ substantially in fitness and transmissibility. Antimicrob. Agent Chemother. 49: 4075-84.
Yen, H. L., A. S. Monto, R. G. Webster, E. A. Govorkova. 2005. Virulence may determine the necessary duration and dosage of oseltamivir treatment for highly pathogenic A/Vietnam/1203/04 (H5N1) influenza virus in mice. J. Infect. Dis. 192: 665-72.