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Li ka Shing Faculty of Medicine
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Guan, Yi
MD(Jiangxi Med Coll), MMedSc(Beijing Union Med), PhD(HK)
Daniel CK Yu Professorship in Virology
Division of Public Health Laboratory Sciences
Contact Information
Tel: 3917 9829 Email:

Prof. Guan is the Director of the State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong. His research focuses on the ecology, evolution and pathogenesis of influenza and other emerging respiratory viruses. Over the past decade, his research team has made distinguished contributions to research in virology and to the control of emerging infectious diseases in China and the world. His contribution to the field is reflected in his publication record of over 260 peer-reviewed articles with >21,000 citations and an h-index of 74.

Prof. Guan’s research on influenza has 1) identified all the major precursors and transmission pathways of the H5N1 influenza viruses that currently circulate in Southeast Asia, Europe and Africa and provided most of the WHO recommended pre-pandemic H5N1 vaccines strains; 2) initiated the systematic study of H9N2 viruses, which, along with H5 viruses, are now regarded as the most likely novel influenza subtypes to cause a pandemic; 3) idefined the critical role of domestic ducks in harboring and spreading influenza viruses; 4) made major contributions in recognizing the emergence, evolutionary history and development of the 2009 H1N1 pandemic virus; and 5) revealed the genesis, infection source, evolutionary pathway and possible transmission route of the recently emerged H7N9 influenza virus.

His work on SARS led to the successful identification of the SARS-Coronavirus and its infectious source from live animal markets and helped the Chinese Government successfully avert the second SARS outbreak in early 2004.

HKU Scholars Hub: Guan, Yi

Selected Publications (Pub Med Search)
  1. Lam TT-Y, Wang J, Shen Y, Zhou B, Duan L, Cheung C-L, Ma C, Lycett SJ, Leung CYH, Chen X, Li F, Hong W, Chai Y, Zhou L, Liang H, Ou Z, Liu  Y, Farooqui, Kelvin DJ, Poon LLM, Smith DK, Pybus OG, Leung GM, Shu Y, Webster RG, Webby RJ, Peiris JSM, Rambaut A, Zhu H*, Guan Y*(2013)The genesis and source of the H7N9 influenza viruses causing human infections in China. Nature2013 Oct 10 [Published Online Aug 21 2013];502(7470):241-4.[impact factor: 38.6, citation: 0]
  2. Zhu H, Wang D, Kelvin DJ, Li L, Zheng Z, Yoon SW, Wong SS, Farooqui A, Wang J, Banner D, Chen R, Zheng R, Zhou J, Zhang Y, Hong W, Dong W, Cai Q, Roehrl MH, Huang SS, Kelvin AA, Yao T, Zhou B, Chen X, Leung GM, Poon LL, Webster RG, Webby RJ, Peiris JS, Guan Y*, Shu Y* (2013) Infectivity, transmission, and pathology of human-isolated H7N9 influenza virus in ferrets and pigs. Science 2013 Jul 12 [Published Online May 23 2013]; 341(6142):183-186.[impact factor: 31.0; citation: 14]
  3. Vijaykrishna D, Smith GDJ,  Pybus OG, Zhu H, Bhatt S, Poon LLM, Riley S, Bahl J, Ma SK, Cheung CL, Perera RAPM,  Chen H, Shortridge KF, Webby RJ, Webster RG,Guan Y*, Peiris JSM*(2011) Long-term evolution and transmission dynamics of swine influenza A virus. Nature 473(7348):519-522. [Impact factor: 38.6, citation: 35]
  4. Vijaykrishna D, Poon LLM, Zhu HC, Ma SK, Li OTW, Cheung CL, Smith GJD, Peiris JSM*, Guan Y*(2010) Reassortment of Pandemic H1N1/2009 Influenza A Virus in Swine. Science 328: 1529-1529.[Impact factor: 31.0; citation: 119]
  5. Smith GJD, Bahl J, Vijaykrishna D, Zhang JX, Poon LLM, Chen H, Webster RG, Peiris JSM,Guan Y*(2009) Dating the emergence of pandemic influenza viruses. Proc Natl Acad Sci U S A 106: 11709-11712.[Impact factor: 9.7; citation: 125]
  6. Smith GJ, Vijaykrishna D, Bahl J, Lycett SJ, Worobey M, Pybus OG, Ma SK, Cheung CL, Raghwani J, Bhatt S, Peiris JS, Guan Y*, Rambaut A*(2009) Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic. Nature 459: 1122-1125.[Impact factor: 38.6; citation: 653]
  7. Zhou BP, Zhong NS, Guan Y*(2007) Treatment with convalescent plasma for influenza A (H5N1) infection. N Engl J Med 357: 1450-1451.[Impact factor: 51.7; citation: 74]
  8. Chen H, Smith GJD, Zhang SY, Qin K, Wang J, Li KS, Webster RG, Peiris JSM, Guan Y*(2005) Avian flu:H5N1 virus outbreak in migratory waterfowl. Nature 436: 191-192.[Impact factor: 38.6; citation: 368]
  9. Guan Y, Peiris JS, Zheng B, Poon LL, Chan KH, Zeng FY, Chan CW, Chan MN, Chen JD, Chow KY, Hon CC, Hui KH, Li J, Li VY, Wang Y, Leung SW, Yuen KY, Leung FC (2004) Molecular epidemiology of the novel coronavirus that causes severe acute respiratory syndrome. Lancet 363: 99-104.[Impact factor: 39.0; citation: 57]
  10. Li KS, Guan Y*, Wang J, Smith GJ, Xu KM, Duan L, Rahardjo AP, Puthavathana P, Buranathai C, Nguyen TD, Estoepangestie AT, Chaisingh A, Auewarakul P, Long HT, Hanh NT, Webby RJ, Poon LL, Chen H, Shortridge KF, Yuen KY, Webster RG, Peiris JS(2004) Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia. Nature 430: 209-213.[Impact factor: 38.6; citation: 675]
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