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Chen, Lu

Chau, Siu Long Matthew, Post-doctoral Fellow, Division of Community Medicine and Public Health Practice, phone: 3917 0975, email: cslmatt@hku.hk
Post-doctoral Fellow

Division of Public Health Laboratory Science

  • BA (Beijing Institute of Technology), PhD (Tsinghua University)
phone 3917 9947
email luchen96@hku.hk
Biography

Dr Chen Lu is currently a Post-doctoral Fellow specialising in arbovirus evolution and host-pathogen interactions. She earned her Ph.D. in Biology from the School of Basic Medical Sciences at Tsinghua University (2024) under the mentorship of Professor Cheng Gong, following her B.S. in Biotechnology from Beijing Institute of Technology (2018). Her doctoral research primarily focuses on virology and infectious diseases, with an emphasis on elucidating the evolutionary adaptation of the dengue virus and exploring host-pathogen interactions in mosquito-borne diseases.

Throughout her doctoral studies, Dr Chen Lu utilised techniques such as viral sequence analysis, reverse genetics, and animal models to investigate viral infectivity and transmission dynamics. Her findings have been published in EMBO Reports and PLoS Pathogens. With a robust technical skill set in molecular biology, biochemistry, cell biology, and animal studies, she is eager to contribute to innovative research on antiviral strategies targeting emerging arboviral threats.
Selected Publications
  1. Lu Chen#, Xianwen Zhang#, Xuan Guo#, Wenyu Peng#, Yibin Zhu, Zhaoyang Wang, Xi Yu, Huicheng Shi, Yuhan Li, Liming Zhang, Lei Wang, Penghua Wang, Gong Cheng. Neighboring mutation-mediated enhancement of dengue virus infectivity and spread. 2022. EMBO reports. 23(11): e55671.
  2. Yuebiao Feng#, Lu Chen#, Li Gao, Li Dong, Han Wen, Xiumei Song, Fang Luo, Gong Cheng*, Jingwen Wang*. Rapamycin inhibits pathogen transmission in mosquitoes by promoting immune activation. 2021. PloS Pathogens. 17(2): e1009353.
  3. Liming Zhang#, Daxi Wang#, Peibo Shi, Juzhen Li, Jichen Niu, Jielong Chen, Gang Wang, Linjuan Wu, Lu Chen, Zhenxing Yang, Susheng Li, Jinxin Meng, Fangchao Ruan, Yuwen He, Hailong Zhao, Zirui Ren, Yibaina Wang, Yang Liu, Xiaolu Shi, Yunfu Wang, Qiyong Liu, Junhua Li, Penghua Wang, Jinglin Wang*, Yibin Zhu*, Gong Cheng*. A naturally isolated symbiotic bacterium suppresses flavivirus transmission by Aedes mosquitoes. 2024. Science.
  4. Linjuan Wu, Liming Zhang, Shengyong Feng, Lu Chen, Cai Lin, Gang Wang, Yinbin Zhu, Penghua Wang, Gong Cheng. An evolutionarily conserved ubiquitin ligase drives infection and transmission of flaviviruses. 2024. Proceedings of the National Academy of Sciences of the United States of America. 121(16): e2317978121.
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