Lan, Yun

Lan, Yun

LY
Post-doctoral Fellow

Division of Public Health Laboratory Sciences

  • BSc (CPU), MSc (KCL), PhD (HKU)
Biography

Dr Yun Lan obtained her MSc degree from King’s College London and completed her PhD degree in Pharmacy and Pharmacology at The University of Hong Kong in 2015. As a trained microbiologist and molecular biologist, her research interests focus on the investigation of the host-virus interactions during virus infection, with particular emphasis on dengue virus (DENV) and zika virus (ZIKV), and their association with host lipogenesis and lipid metabolism.

Selected Publications
  1. Zhang JS#, Lan Y#, Sanyal S*. Modulation of lipid droplet metabolism — a potential target for therapeutic intervention in flaviviridae infections. (2017) Frontier in Microbiology  doi: 10.3389/fmicb.2017.02286
  2. Kwok PCL,  Grabarek A, Chow MYT, Lan Y, Li JCW, Casettari L, et al. (2015) Inhalable spray-dried formulation of D-LAK Antimicrobial peptides targeting tuberculosis. International Journal of Pharmaceutics 491 (1-2): 367-374
  3. Lan Y, Lam JT, Siu GKH, Yam WC, Mason AJ, Lam JKW. (2014) Cationic amphipathic D-enantiomeric antimicrobial peptides with in vitro and ex vivo activity against drug-resistant Mycobacterium tuberculosis. Tuberculosis 94 (6): 678-689
  4. Abbate V, Liang W, Patel J, Lan Y, Capriotti L, Iacobucci V, et al. (2013) Manipulating the pH response 2, 3-diaminopropionic acid rich peptides mediate highly effective and non-toxic gene silencing.  Journal of Controlled Release 172 (3): 929-938
  5. Tripathy N, Lan Y, Lam JKW, Vanhoutte PM, Hahn YB (2013) Comprehensive study on the toxicology of surface-coated ZnO nanoparticles in human alveolar adenocarcinoma (A549) cells. Science of Advanced Materials 5 (4): 421-429
  6. Vermeer LS, Lan Y, Abbate V, Ruh E, Bui TT, Wilkinson L, et al. (2012) Conformational flexibility determines selectivity and anti-bacterial, -plasmodium, and –cancer potency of cationic α-helical peptides. Journal of Biological Chemistry 287 (41): 34120-34133
  7. Lam JKW, Liang W, Lan Y, Chaudhuri P, Chow MYT, Witt K, et al. (2012) Effective endogenous gene silencing mediated by pH responsive peptides proceeds via multiple pathways. Journal of Controlled Release 158 (2): 293-303
  8. Lan Y, Yan Y, Kozlowska J, Lam JKW, Drake A, Mason AJ (2010) Structural contributions to the intracellular targeting strategy of antimicrobial peptides. Biochimica et Biophysica Acta – Biomembranes 1798 (10): 1934-1943
  9. Lan Y, Langlet-Bertin B,  Abbate V,  Vermeer LS,  Kong  XL, Sullivan KE, Leborgne C, Scherman D, Hider RC, Drake AF, Bansal SS, Kichler A, Mson AJ (2010) Incorporation of 2,3-diaminopropionic acid into linear cationic amphipathic peptides produces pH-sensitive vectors. ChemBioChem 11(9):1266-1272
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