Dr Luo Shan holds a Master’s degree with distinction in Public Health and a PhD in Epidemiology and Biostatistics from the University of Hong Kong. She received exchange training at the MRC Integrative Epidemiology Unit in the UK.

Her research focuses on identifying the determinants of non-communicable diseases, and exploring the safety, validation and repositioning of drug targets. By leveraging human genetics and genomics, and utilizing Mendelian randomization to improve causal inference, she aims to address unmet needs in pharmacological intervention. Her work includes the identification of novel drug targets for rare diseases, evaluation of drug safety in pediatric populations, and repositioning drug targets, notably metformin, to promote healthy longevity.

She received the Bau Tsu Zung Bau Kwan Yeu Hing Research and Clinical Fellowship (2019), Research Output Prize (2020), Healthy Longevity Catalyst Award from the US  National Academy of Medicine (2021), and the World Cancer Research Fund Inspire Research Challenge (2023).

1. Wong THT, Mo JMY, Zhou M, Zhao J, Schooling CM, He B, Luo S,* Au Yeung SL. A two-sample Mendelian randomization study explores metabolic profiling of different glycemic traits. Communications Biology. 2024;7(1):293. [IF (2023): 5.2, Biology: Ranked 10/109]
2. Luo S, Lam HS, Chan YH, Tang CSM, He B, Kwok MK, Leung GM, Schooling CM, Au Yeung SL. Assessing the safety of lipid-modifying medications amongst Chinese adolescents: a drug-target Mendelian randomization study. BMC Medicine. 2023Oct 31;21(1):410. [IF (2023): 7, Medicine, General & Internal: Ranked 19/329]
3. Luo S,* Wong ICK, Chui CSL, Zheng J, Huang Y, Schooling CM, Au Yeung SL. Effects of putative metformin targets on phenotypic age and leukocyte telomere length: A mendelian randomisation study using data from the UK Biobank. Lancet Healthy Longevity. 2023 Jul;4(7):e337-e344. [IF (2023): 13.4, Geriatrics & Gerontology: Ranked 2/74]
4. Luo S, Liang Y, Wong THT, Schooling CM, Au Yeung SL. Identifying factors contributing to increased susceptibility to COVID-19 risk: a systematic review of Mendelian randomization studies. International Journal of Epidemiology. 2022 Apr 20:dyac076. [IF (2021): 9.685, Public, Environment & Occupational Health: Ranked 16/210]
5. Luo S, Au Yeung SL, Schooling CM. Assessing the linear and non-linear association of HbA1c with cardiovascular disease: a Mendelian randomisation study. Diabetologia 2021 Nov;64(11):2502-10. [IF (2021): 10.460; Endocrinology & Metabolism: Ranked 11/146]
6. Luo S,* Clarke SLN, Ramanan AV, Thompson S, Langefeld CD, Marion MC, Grom AA, Schooling CM, Gaunt TR, Au Yeung SL, Zheng J. Platelet glycoprotein Ib alpha chain as a putative therapeutic target for juvenile idiopathic arthritis: a Mendelian randomization study. Arthritis and Rheumatology. 2021 Apr; 73(4): 693-701 [IF (2021): 15.483; Rheumatology: Ranked 4/34]
7. Luo S, Schooling CM, Wong ICK, Au Yeung SL. Evaluating the impact of AMPK activation, a target of metformin on risk of cardiovascular diseases and cancer in the UK Biobank: a Mendelian randomization study. Diabetologia. 2020 Nov;63(11):2349-58. [IF (2020): 10.122; Endocrinology & Metabolism: Ranked 9/146]
8. Luo S, Au Yeung SL, Zuber V, Burgess S, Schooling CM. The impact of genetically predicted red blood cell traits on venous thromboembolism, multivariable Mendelian randomization study using UK Biobank. Journal of the American Heart Association. 2020 Jul 21;9(14):e016771. [IF (2020): 5.501; Cardiac & Cardiovascular Systems: Ranked 35/142]
9. Au Yeung SL, Luo S, Schooling CM. The impact of GDF-15, a biomarker for metformin, on the risk of coronary artery disease, breast and colorectal cancer, and type 2 diabetes and metabolic traits: a Mendelian randomisation study. Diabetologia, 2019 Sept. 62(9): p. 1638-46 [IF (2019): 7.518; Endocrinology & Metabolism: Ranked 10/143]
10. Luo S, Au Yeung SL, Zhao J, Burgess S, Schooling CM. Association of genetically predicted testosterone with thromboembolism, heart failure, and myocardial infarction: mendelian randomization study in UK Biobank. BMJ. 2019 Mar 6; 364: l476. [IF (2019): 30.313, Medicine, General & Internal: Rank 4/172] (Selected as Research Output Prize 2019-2020, Li Ka Shing Faculty of Medicine, The University of Hong Kong)
11. Au Yeung SL, Luo S, Schooling CM. The Impact of Glycated Hemoglobin (HbA1c) on Cardiovascular Disease Risk: A Mendelian Randomization Study Using UK Biobank. Diabetes Care 2018 Sept;41(9):1991-97 [IF (2018): 15.270; Endocrinology & Metabolism: Ranked 4/145]