Dr Daniel Chu obtained his PhD in Virology from the University of Hong Kong in 2013. His PhD thesis focused on viruses at the transmission interface between humans and other animals. His works during PhD have significantly contributed to the knowledge on the diversity of coronaviruses and astroviruses in mammalian and avian hosts, and to our understanding on the ecology and evolution of these viruses in humans and in nature. His PhD study has generated 5 journal publications and his thesis has been ranged within top 10% by an external examiner.
His current research focus on the ecology and evolution of Middle East Respiratory Syndrome (MERS) coronavirus in humans and in camels. He is interested in epidemiology study of the transmission of MERS coronavirus within humans, camels as well as the transmission between these hosts. His current research also involve studying of virus evolution using next generation sequencing technologies. And he is responsible for developing a diagnostic laboratory for influenza and other clinical respiratory viruses in the School.
Chan RW, Hemida MG, Kayali G, Chu DK, Poon LL, Alnaeem A, Ali MA, Tao KP, Ng HY, Chan MC, Guan Y, Nicholls JM, Peiris JS. Tropism and replication of Middle East respiratory syndrome coronavirus from dromedary camels in the human respiratory tract: an in-vitro and ex-vivo study. Lancet Respir Med. 2014 Oct;2(10):813-22. doi: 10.1016/S2213-2600(14)70158-4. Epub 2014 Aug 28. PubMed PMID: 25174549.
Hemida MG, Chu DK, Poon LL, Perera RA, Alhammadi MA, Ng HY, Siu LY, Guan Y, Alnaeem A, Peiris M. MERS coronavirus in dromedary camel herd, Saudi Arabia. Emerg Infect Dis. 2014 Jul;20(7):1231-4. doi: 10.3201/eid2007.140571. PubMed PMID: 24964193; PubMed Central PMCID: PMC4073860.
Chu DK, Poon LL, Gomaa MM, Shehata MM, Perera RA, Abu Zeid D, El Rifay AS, Siu LY, Guan Y, Webby RJ, Ali MA, Peiris M, Kayali G. MERS coronaviruses in dromedary camels, Egypt. Emerg Infect Dis. 2014 Jun;20(6):1049-53. doi: 10.3201/eid2006.140299. PubMed PMID: 24856660; PubMed Central PMCID: PMC4036765.
Wertheim JO, Chu DK, Peiris JS, Kosakovsky Pond SL, Poon LL. A case for the ancient origin of coronaviruses. J Virol. 2013 Jun;87(12):7039-45. doi: 10.1128/JVI.03273-12. Epub 2013 Apr 17. PubMed PMID: 23596293; PubMed Central PMCID: PMC3676139.
Chu DK, Leung CY, Perera HK, Ng EM, Gilbert M, Joyner PH, Grioni A, Ades G, Guan Y, Peiris JS, Poon LL. A novel group of avian astroviruses in wild aquatic birds. J Virol. 2012 Dec;86(24):13772-8. doi: 10.1128/JVI.02105-12. Epub 2012 Oct 3. PubMed PMID: 23035212; PubMed Central PMCID: PMC3503074.
Chu DK, Poon LL, Chiu SS, Chan KH, Ng EM, Bauer I, Cheung TK, Ng IH, Guan Y, Wang D, Peiris JS. Characterization of a novel gyrovirus in human stool and chicken meat. J Clin Virol. 2012 Nov;55(3):209-13. doi:10.1016/j.jcv.2012.07.001. Epub 2012 Jul 21. PubMed PMID: 22824231; PubMed Central PMCID: PMC3449218.
Chu DK, Leung CY, Gilbert M, Joyner PH, Ng EM, Tse TM, Guan Y, Peiris JS, Poon LL. Avian coronavirus in wild aquatic birds. J Virol. 2011Dec;85(23):12815-20. doi: 10.1128/JVI.05838-11. Epub 2011 Sep 28. PubMed PMID: 21957308; PubMed Central PMCID: PMC3209365.
Chu DK, Chin AW, Smith GJ, Chan KH, Guan Y, Peiris JS, Poon LL. Detection of novel astroviruses in urban brown rats and previously known astroviruses in humans. J Gen Virol. 2010 Oct;91(Pt 10):2457-62. doi: 10.1099/vir.0.022764-0. Epub 2010 Jun 16. PubMed PMID: 20554799; PubMed Central PMCID: PMC3052596.
Zhu HC, Chu DK, Liu W, Dong BQ, Zhang SY, Zhang JX, Li LF, Vijaykrishna D, Smith GJ, Chen HL, Poon LL, Peiris JS, Guan Y. Detection of diverse astroviruses from bats in China. J Gen Virol. 2009 Apr;90(Pt 4):883-7. doi: 10.1099/vir.0.007732-0. Epub 2009 Mar 4. PubMed PMID: 19264622.
Chu DK, Poon LL, Guan Y, Peiris JS. Novel astroviruses in insectivorous bats. J Virol. 2008 Sep;82(18):9107-14. doi: 10.1128/JVI.00857-08. Epub 2008 Jun 11. PubMed PMID: 18550669; PubMed Central PMCID: PMC2546893.
Chu DK, Peiris JS, Chen H, Guan Y, Poon LL. Genomic characterizations of bat coronaviruses (1A, 1B and HKU8) and evidence for co-infections in Miniopterus bats. J Gen Virol. 2008 May;89(Pt 5):1282-7. doi: 10.1099/vir.0.83605-0. PubMed PMID: 18420807.