Hui, Pui Yan Kenrie

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BSc(HK), MPhil(HK), PhD(HK)
 
Research Assistant Professor
Division of Public Health Laboratory Sciences
 
Contact Information
Tel: 3917 7530
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

Biography

Dr Kenrie Hui received her Ph.D. from the Department of Microbiology in The University of Hong Kong, and her postdoctoral training at Centre of Influenza Research, School of Public Health, The University of Hong Kong. Since her Ph.D. study, she mainly works on the innate immunity during influenza A (H5N1) infection, signaling pathways of cytokine induction including the role of innate sensing receptors in cytokine induction and amplification of cytokine production.

Her research interests focus on understanding the pathogenesis of highly pathogenic influenza A viruses, exploring cellular targets as novel therapeutic options for severe influenza disease, and examining the tropism and immune responses of emerging respiratory viruses (influenza and MERS) in ex vivo cultures and primary cell models derived from human respiratory tract.

Dr Hui was awarded Croucher Foundation Research Studentships and Butterfield-Croucher Studentship during her Ph.D. study. She received the Boehringer Ingelheim Fonds Travel Grant and Promising Investigator Scholarship in the Options for the Control of Influenza VII in 2010. She was awarded Keystone Symposia Scholarship in the Keystone Symposia in 2011.

HKU Scholars Hub: Hui, Pui Yan Kenrie

 

Selected Publications  (Pub Med Search)

  1. Hui KPY, Ching RHH, Chan SKH, Nicholls JM, Sachs N, Clevers H, Peiris JSM, Chan MCW (2018) Assessment of influenza virus tropism, replication competence and innate immune responses: a prospective comparative study of human airway organoids and ex-vivo bronchus cultures. Lancet Respiratory Medicine. 2018 Jun (In Press) (Impact factor: 19.3).
  2. Li HS, Kuok DIT, Cheung MC, Ng MMT, Ng KC, Hui KPY, Peiris JSM, Chan MCW, Nicholls JM (2018) Effect of interferon alpha and cyclosporine treatment separately and in combination on Middle East Respiratory Syndrome Coronavirus (MERS-CoV) replication in a human in-vitro and ex-vivo culture model. Antiviral Res. 2018 May 17;155:89-96. (In Press) (Impact factor: 4.3).
  3. Chu DKW, Hui KPY, Perera RAPM, Miguel E, Niemeyer D, Zhao J, Channappanavar R, Dudas G, Oladipo JO, Traoré A, Fassi-Fihri O, Ali A, Demissié GF, Muth D, Chan MCW, Nicholls JM, Meyerholz DK, Kuranga SA, Mamo G, Zhou Z, So RTY, Hemida MG, Webby RJ, Roger F, Rambaut A, Poon LLM, Perlman S, Drosten C, Chevalier V, Peiris M. MERS coronaviruses from camels in Africa exhibit region-dependent genetic diversity. Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):3144-3149.(Impact factor: 9.7).
  4. Hui KP, Chan LLY, Kuok DIT, Mok CKP, Yang ZF, Li RF, LukGSM, LeeEF, Lai JCC, Yen HL, Zhu HC, Guan Y, Nicholls JM, Peiris JSM, Chan MCW. Tropism and innate host responses of influenza A/H5N6 virus: an analysis of ex-vivo and in-vitro cultures of the human respiratory tract.European Respiratory Journal, 2017 Mar 8;49(3).(Impact factor: 10.6; citation: 3).
  5. Hui KP, Li HS, Cheung MC, Chan RW, Yuen KM, Mok CK, Nicholls JM, Peiris JSM, Chan MC. Highly pathogenic avian influenza H5N1 virus delays apoptotic responses via activation of STAT3.Sci Rep, 2016 Jun 27;6:28593.  (Impact factor: 4.3; citation: 5).
  6. Kenrie PY Hui, Denise IT Kuok, Sara SR Kang, Hung-Sing Li, Mandy MT Ng, Christine HT Bui, JS Malik Peiris, Renee WY Chan, Michael CW Chan. Modulation of sterol biosynthesis regulates viral replication and cytokine production in influenza A virus infected human alveolar epithelial cells, Antiviral Research, 2015 Jul;119, 1-7. (Impact factor: 4.3; citation: 2)
  7. MCW Chan, DIT Kuok, CYH Leung, KPY Hui, Valkenburg SA, Lau EH, Nicholls JM, Fang X, Guan Y, Lee JW, Chan RW, Webster RG, Matthay MA, Peiris JS. Human mesenchymal stromal cells reduce influenza A H5N1-associated acute lung injury in vitro and in vivo, PNAS, 2016 Mar;113(13):3621-6. (Impact Factor: 9.7; citation: 19).
  8. Chan MC, Chan RW, Chan LL, Mok CK, Hui KP, Fong JH, Tao KP, Poon LL, Nicholls JM, Guan Y, Peiris JS. Tropism and innate host responses of a novel avian influenza A H7N9 virus: an analysis of ex-vivo and in-vitro cultures of the human respiratory tract.Lancet Respir Med. 2013 Sep;1(7), 534-42.(Impact factor: 19.3; citation: 43).
  9. Cheung CY, Chan EY, Krasnoselsky A, Purdy D, Navare AT, Bryan JT, Leung CK, Hui KP, Peiris JS, Katze MG. H5N1 virus causes significant perturbations in host proteome very early in influenza virus-infected primary human monocyte-derived macrophages. J Infect Dis.2012 Sep 1;206(5), 640-5. (Impact factor: 6.3; citation: 14).
  10. Hui K.P.Y., Lee M.Y., Cheung C.Y., Mao H., Lai A.K.W., Chan R.W.Y., Chan M.C.W., Tu W., Guan Y., Lau Y.L. and Peiris J.S.M. H5N1 Influenza Virus-induced Mediators Up-regulate RIG-I in Uninfected Cells by Paracrine Effects Contributing to Amplified Cytokine Cascades, The Journal of Infectious Diseases, 2011, 204, 1866-78. (Impact factor: 6.3; citation: 23).
  11. Peiris J.S.M., Hui K.P.Y. and Yen H. Host response to influenza virus: protection versus immunopathology, Current Opinion in Immunology, 2010, 22, 475-481. (Impact factor: 8.4; citation: 79).
  12. Hui K.P.Y., Lee M.Y., Cheung C.Y., Ng I.H.Y., Poon L.L.M., Guan Y., Ip N.Y.Y., Lau A.S.Y. and Peiris J.S.M. Induction of proinflammatory cytokines in primary human macrophages by influenza A virus (H5N1) is selectively regulated by IFN regulatory factor 3 and p38 MAPK, The Journal of Immunology, 2009, 182, 1088-1098. (Impact factor: 4.9; citation: 99).

 

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