Assistant Professor (joint appointment with School of Biomedical Sciences)
Division of Public Health Laboratory Sciences
Dr Sumana Sanyal is a biochemist by training with an interest in aspects of host pathogen interactions including influenza, dengue and related viruses. She obtained her PhD from Cornell University, USA and postdoctoral training from the Whitehead Institute/MIT. Her current research includes identification and characterization of host factors important in virus pathogenesis. Using a combination of genetics and proteomics-based approaches her research group is investigating how post translational modifications, especially the ubiquitylation machinery, are targeted and alter protein function during cellular perturbations such as in virus infections, either to facilitate replication and pathogenesis or in installing a host immune response.
Zhang J, LanY, Li MY, Lamers MM, Fusade-Boyer M, Klemm E, Thiele C, Ashour J and Sanyal S*. Flaviviruses exploit the lipid droplet protein AUP1 to trigger lipophagy and drive virus production (2018)Cell Host Microbe. 23 (6):819-831
Fan Y, Sanyal S*, Bruzzone R*. Breaking Bad. How viruses subvert the cell cycle. Front Cell Infect Microbio. (2018) Nov 19; (8): 396
Pombo JP and Sanyal S*. Perturbation of cholesterol and fatty acid homeostasis during flavivirus infections (2018) Front Immunol. June 4; 9: 1276
Zhang J, LanY and Sanyal S*. Modulation of lipid droplet metabolism – a potential target for therapeutic intervention in Flaviviridae infections. (2017) Front Microbiol. Nov 28; 8: 2286
Fan Y, Mok CK, Kein F, Bruzzone R* and Sanyal S*. Cell-cycle independent role of CyclinD3 in host restriction of influenza infection (2017) J Biol Chem292(12): 5070-5088
Sanyal S*. Reply to Rodriguez: Mechanism of nuclear-cytosol shuttling of Usp12 (2016) Proc Natl Acad Sci USA 113(24): E3317-18
Jahan AS, Lestra M, Swee LK, Fan Y, Lamers MM, Tafesse FG, Theile CS, Spooner E, Bruzzone R, Ploegh HL and Sanyal S*. Usp12 stabilizes the T-cell receptor at the cell surface during signaling (2016) Proc Natl Acad Sci USA 113(6): E705-14 *corresponding author
Lin YP, Luo Y, Chen Y, Lamers MM, Zhou Q, Yang XH, Sanyal S, Mok CK, Liu ZM. Clinical and epidemiological features of the 2014 large-scale dengue outbreak in Guanzhou city, China (2016) BMC Infect Dis 16(1): 102
Claessen JHL, Sanyal S and Ploegh H. The chaperone Bag6 captures dislocated glycoproteins in the cytosol (2014) PloS One 9(3):e90204.
Sanyal S, Ashour J, Maruyama T, Altenburg AF, Cragnolini JJ, Bilate A, Avalos AM, Garcia-Sastre A and Ploegh HL. Type-I interferon imposes a Tsg101/ISG15 checkpoint at the Golgi for glycoprotein trafficking during influenza virus infection (2013) Cell Host Microbe 14(5): 510-521
Reiling JH, Olive AJ, Sanyal S, Carette JE, Brummelkamp TR, Ploegh HL, Starnbach MN and Sabatini DM. A Luman/CREB3–ADP-ribosylation factor 4 (ARF4) signaling pathway mediates the response to Golgi stress and susceptibility to pathogens (2013) Nat Cell Biology 15(12): 1473-1485.
Tafesse F, Sanyal S, Ashour J, Guimaraes CP, Hermansson M, Somerharju P and Ploegh H. (2013) Intact sphingomyelin biosynthetic pathway is essential for intracellular transport of Influenza virus glycoproteins Proc Natl Acad Sci USA 110(16): 6406-6411
Sanyal S, Claessen JHL and Ploegh H (2012) A viral deubiquitylating enzyme restores dislocation of substrates from the endoplasmic reticulum (ER) in semi-intact cells. J. Biol. Chem 287(28): 23594-23603
Ernst R, Claessen JHL, Mueller B, Sanyal S, Spooner E, van der Veen AG, Kirak O, Schlieker C, Weihofen WA and Ploegh H (2011) Enzymatic blockade of the ubiquitin proteasome pathway. PLoS Biol 8(3): e1000605
Menon I, Huber T, Sanyal S, Banerjee S, Barre P, Canis S, Warren JD, Hwa J, Sakmar T and Menon AK (2011) Opsin is a phospholipid flippase in disk membranes. Curr Biol 21(2): 149-153
Sanyal Sand Menon AK (2010) Stereoselective transbilayer translocation of mannosyl phosphoryl dolichol by an endoplasmic reticulum flippase. Proc Natl Acad Sci USA 107(25): 11289-11294
Sanyal Sand Menon AK (2009) Flipping lipids: Why an’ what’s the reason for? ACS Chem Biol; Invited review 4(11): 895-909
Sanyal Sand Menon AK (2009) Specific transbilayer translocation of dolichol-linked-oligosaccharides by an endoplasmic reticulum flippase. Proc Natl Acad Sci USA 106(3): 767-772
Frank CG, Sanyal S and Menon AK (2008) Does Rft1 flip an N-glycan lipid precursor? Nature 454(7204): E3-4
Sanyal S, Frank CG, Menon AK (2008) Distinct flippases translocate glycerophospholipids and oligosaccharide diphosphate dolichols across the endoplasmic reticulum. Biochemistry 47(30): 7937-7946 (ACS Chemical Biology spotlight, Vol 3 No. 8)
Sutterwala SS, Creswell CH, Sanyal S, Menon AK and Bangs JD (2007) De novo sphingolipid synthesis is essential for viability, but not for transport of glycosylphosphatidylinositol-anchored proteins, in African trypanosomes. Eukaryot Cell 6(3): 454-464