管轶

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MD(Jiangxi Med Coll), MMedSc(Beijing Union Med), PhD(HK)
 
于崇光基金教授席(病毒学)
新发病毒性疾病学讲座教授
组长(流感及重点传染病)
 
联络资料
电话: 3917 9829
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个人简介

管轶教授为香港大学新发传染性疾病国家重点实验室主任以及流感研究中心主任。其研究集中在流感和其他新发呼吸道病毒的生态、演化和发病机制。管轶博士的研究团队在过去十年中为病毒学研究和中国乃至全世界控制新发传染病方面作出了杰出贡献,发表同行评审论文300余篇,论文引用次数超过36000次,H指数高达92 。

管教授在流感方面的研究已1)确定了现时在东南亚、欧洲和非洲地区传播的H5N1流感病毒的所有主要前体和传播途径, 提供了世卫组织提出的大多数大流行前期H5N1疫苗株; 2)开展了H9N2病毒的系统研究,该病毒与H5病毒被视为最可能导致流行病的新流感亚型;3)确定了家鸭在携带和传播流感病毒中的关键作用;4)为识别2009年H1N1流行性病毒的出现、演化史和发展作出了重要贡献;5)揭示了近期出现的H7N9流感病毒的发生、传染源、演化过程和可能的传播途径。

管教授在SARS方面的工作成功确定了SARS冠状病毒及其活禽畜市场的传染源,帮助内地政府成功避免了2004年年初SARS的再次爆发。

管教授近期被评为高引用频次研究学者(2014, 2015, 2016, 2017, 2018),微生物领域世界排名第11(汤森路透)。他获得了来自美国国立卫生研究院、威康信托基金会、世卫组织及 本地政府和私人基金会的资助金。美国《时代》杂志曾两次报导管教授,称其为18名「全球卫生英雄』之一和「亚洲英雄」。

HKU Scholars Hub: Guan, Yi

 

发表的部分文章  (Pub Med Search)

  1. Lam TT-Y, Wang J, Shen Y, Zhou B, Duan L, Cheung C-L, Ma C, Lycett SJ, Leung CYH, Chen X, Li F, Hong W, Chai Y, Zhou L, Liang H, Ou Z, Liu  Y, Farooqui, Kelvin DJ, Poon LLM, Smith DK, Pybus OG, Leung GM, Shu Y, Webster RG, Webby RJ, Peiris JSM, Rambaut A, Zhu H*, Guan Y*(2013)The genesis and source of the H7N9 influenza viruses causing human infections in China. Nature. 502(7470):241-4. [impact factor: 38.6, citation: 76]
  2. Zhu H, Wang D, Kelvin DJ, Li L, Zheng Z, Yoon SW, Wong SS, Farooqui A, Wang J, Banner D, Chen R, Zheng R, Zhou J, Zhang Y, Hong W, Dong W, Cai Q, Roehrl MH, Huang SS, Kelvin AA, Yao T, Zhou B, Chen X, Leung GM, Poon LL, Webster RG, Webby RJ, Peiris JS, Guan Y*, Shu Y* (2013) Infectivity, transmission, and pathology of human-isolated H7N9 influenza virus in ferrets and pigs. Science. 341(6142):183-186. [impact factor: 31.0; citation: 99]
  3. Vijaykrishna D, Smith GDJ,  Pybus OG, Zhu H, Bhatt S, Poon LLM, Riley S, Bahl J, Ma SK, Cheung CL, Perera RAPM,  Chen H, Shortridge KF, Webby RJ, Webster RG, Guan Y*, Peiris JSM*(2011) Long-term evolution and transmission dynamics of swine influenza A virus. Nature. 473(7348):519-522. [Impact factor: 38.6, citation: 70]
  4. Vijaykrishna D, Poon LLM, Zhu HC, Ma SK, Li OTW, Cheung CL, Smith GJD, Peiris JSM*, Guan Y*(2010) Reassortment of Pandemic H1N1/2009 Influenza A Virus in Swine. Science. 328: 1529-1529. [Impact factor: 31.0; citation: 170]
  5. Smith GJD, Bahl J, Vijaykrishna D, Zhang JX, Poon LLM, Chen H, Webster RG, Peiris JSM, Guan Y*(2009) Dating the emergence of pandemic influenza viruses. Proc Natl Acad Sci U S A. 106: 11709-11712.[Impact factor: 9.7; citation: 162]
  6. Smith GJ, Vijaykrishna D, Bahl J, Lycett SJ, Worobey M, Pybus OG, Ma SK, Cheung CL, Raghwani J, Bhatt S, Peiris JS, Guan Y*, Rambaut A*(2009) Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic. Nature. 459: 1122-1125.[Impact factor: 38.6; citation: 875]
  7. Zhou BP, Zhong NS, Guan Y*(2007) Treatment with convalescent plasma for influenza A (H5N1) infection. N Engl J Med. 357: 1450-1451.[Impact factor: 51.7; citation: 105]
  8. Chen H, Smith GJD, Zhang SY, Qin K, Wang J, Li KS, Webster RG, Peiris JSM, Guan Y*(2005) Avian flu:H5N1 virus outbreak in migratory waterfowl. Nature. 436: 191-192.[Impact factor: 38.6; citation: 474]
  9. Guan Y, Peiris JS, Zheng B, Poon LL, Chan KH, Zeng FY, Chan CW, Chan MN, Chen JD, Chow KY, Hon CC, Hui KH, Li J, Li VY, Wang Y, Leung SW, Yuen KY, Leung FC (2004) Molecular epidemiology of the novel coronavirus that causes severe acute respiratory syndrome. Lancet. 363: 99-104.[Impact factor: 39.0; citation: 69]
  10. Li KS, Guan Y*, Wang J, Smith GJ, Xu KM, Duan L, Rahardjo AP, Puthavathana P, Buranathai C, Nguyen TD, Estoepangestie AT, Chaisingh A, Auewarakul P, Long HT, Hanh NT, Webby RJ, Poon LL, Chen H, Shortridge KF, Yuen KY, Webster RG, Peiris JS(2004) Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia. Nature. 430: 209-213.[Impact factor: 38.6; citation: 928]

 

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