Au Yeung, Shiu Lun Ryan

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Assistant Professor

Division of Epidemiology and Biostatistics

  • BSc (HKU), MPH (HKU), PhD (HKU)

     

Biography

Dr Ryan Au Yeung joined the School of Public Health, the University of Hong Kong after his Master of Public Health training (with distinction) in 2008 and PhD training in 2012 at the University of Hong Kong.

Dr Au Yeung’s primary research interests include the determinants and consequences of cardiovascular diseases and diabetes, health effects of medications, and health effects of alcohol using longitudinal cohort studies and Mendelian randomization. His more recent work relates to the design of Mendelian randomization studies using UK Biobank and summary statistics from genome wide association studies to explore the pleiotropic effects of medications for cardiovascular diseases and type 2 diabetes (e.g. metformin). He currently leads a 5-year Health and Medical Research Fund commissioned study on “Children of 1997” birth cohort focusing on data enrichment (e.g. generating GWAS and microbiome data).

Dr Au Yeung has 87 publications listed at Scopus, with an H-index of 15 (August, 2021). Dr Au Yeung was awarded the Health and Medical Research Fund Research Fellowship (2014), the American Journal of Epidemiology (AJE) Article of the Year (2015), and the Research Output Prize, LKS Faculty of Medicine, HKU (2020). Dr Au Yeung is currently an editorial board member of Scientific Reports.

Dr Au Yeung has been involved in teaching at undergraduate and postgraduate level, including global health, epidemiology, and evidence based practice. Dr Au Yeung was the Deputy Programme Director of the Bachelor of Arts and Sciences in Global Health and Development [BASc(GHD)] from 2018-2021.

Selected Publications

(*Denotes corresponding author, † Denotes joint senior author)

  1. Luo S, Au Yeung SL*, Schooling CM. Assessing the linear and non-linear association of glycated hemoglobin with cardiovascular disease: A Mendelian randomization study. Diabetologia. 2021. [epub ahead of print] [IF (2020): 10.1 [Endocrinology and Metabolism: Ranked 9/145]] [https://pubmed.ncbi.nlm.nih.gov/34345974/]
  2. Au Yeung SL*, Borges MC, Lawlor DA, Schooling CM. The impact of lung function on cardiovascular diseases and cardiovascular risk factors: a two sample bi-directional Mendelian randomization study. Thorax. 2021 [IF (2020): 9.1 [Respiratory system: Ranked 7/64]] [https://pubmed.ncbi.nlm.nih.gov/34155093/]
  3. Au Yeung SL*, Zhao JV, Schooling CM. Evaluation of glycemic traits in susceptibility to COVID-19 risk: A Mendelian randomization study. BMC Medicine. 2021. 19: 72 [IF (2020): 8.8 [Medicine, General, and Internal: Ranked 13/169]] [https://pubmed.ncbi.nlm.nih.gov/33757497/]
  4. Au Yeung SL*, Schooling CM. Impact of urinary sodium on cardiovascular disease and risk factors: a 2 sample Mendelian randomization study. Clinical Nutrition. 2021. 40: 1990-1996 [IF (2020): 7.3 [Nutrition and Dietetics: Ranked 7/89]] [https://pubmed.ncbi.nlm.nih.gov/33004230/]
  5. Luo S, Clarke S, Ramanan A, Thompson S, Langefeld CD, Grom AA, Schooling CM†, Gaunt TR†, Au Yeung SL†, Zheng J†. Platelet glycoprotein Ib alpha chain as a putative therapeutic target for juvenile idiopathic arthritis: a Mendelian randomization study. Arthritis and Rheumatology. 2021. 73: 693-701 [IF (2020): 11.0 [Rheumatology: Ranked 3/34]] [https://pubmed.ncbi.nlm.nih.gov/33079445/]
  6. Luo S, Schooling CM, Wong ICK, Au Yeung SL*. Evaluating the impact of AMPK activation, a target of metformin, on risk of cardiovascular diseases and cancer in the UK Biobank: A Mendelian randomization study. Diabetologia. 2020. 63: 2349-2358 [IF (2019): 7.5 [Endocrinology and Metabolism: Ranked 10/143]] [https://pubmed.ncbi.nlm.nih.gov/32748028/]
  7. Au Yeung SL*, Luo S, Schooling CM. The impact of GDF-15, a biomarker for metformin, on the risk of coronary artery disease, breast and colorectal cancer, and type 2 diabetes and metabolic traits: a Mendelian randomisation study. Diabetologia. 2019. 62: 1638-1646 [IF (2018): 7.1 [Endocrinology and Metabolism: Ranked 12/140]] [https://pubmed.ncbi.nlm.nih.gov/31161347/]
  8. Luo S, Au Yeung SL, Zhao JV, Burgess S, Schooling CM. The association of genetically predicted testosterone with thromboembolism, heart failure and myocardial infarction: a Mendelian randomization study using UK Biobank. British Medical Journal. 2019. 364: l476 [IF (2018): 27.6 [Medicine, General, and Internal: Ranked 5/160]] (Selected as Research Output Prize, The University of Hong Kong) [https://pubmed.ncbi.nlm.nih.gov/30842065/]
  9. Au Yeung SL*, Luo S, Schooling CM. The impact of glycated hemoglobin (HbA1c) on cardiovascular disease risk: A Mendelian randomization study using UK Biobank. Diabetes Care. 2018. 41: 1991-1997 [IF (2017): 13.4 [Endocrinology and Metabolism: Ranked 5/142]] [https://pubmed.ncbi.nlm.nih.gov/29950300/]
  10. Au Yeung SL, Jiang C, Long M, Cheng KK, Liu B, Zhang W, Lam TH, Leung, GM, Schooling CM. Evaluation of moderate alcohol use with QT interval and heart rate using Mendelian randomization analysis among older Southern Chinese men in the Guangzhou Biobank Cohort Study. American Journal of Epidemiology. 2015 182: 320-327 (Selected as the 2015 Articles of the Year) [IF (2014): 5.2 [Public, Environmental and Occupational Health: Ranked 9/165]] [https://pubmed.ncbi.nlm.nih.gov/26153479/]
 



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