Au Yeung, Shiu Lun Ryan

AYR
Assistant Professor

Division of Epidemiology and Biostatistics

  • BSc (HKU), MPH (HKU), PhD (HKU)

     

Biography

Dr Ryan Au Yeung joined the School of Public Health, the University of Hong Kong after his MPH training (with distinction) in 2008 and PhD training in 2012 at the University of Hong Kong. Dr Au Yeung is currently the Deputy Programme Director of the Bachelor of Arts of Sciences in Global Health and Development [BASc(GHD)].

Dr Au Yeung’s primary research interests include the determinants and consequences of cardiovascular diseases and diabetes, health effects of medications, and health effects of alcohol using longitudinal cohort studies and Mendelian randomization. In recent years, Dr Au Yeung has used Mendelian randomization studies to explore the determinants of cardiovascular diseases, including lung function and glycemic traits. His more recent work relates to the design of Mendelian randomization studies using UK Biobank and summary statistics from genome wide association studies to explore the pleiotropic effects of medications for diabetes (e.g. metformin).

Dr Au Yeung has 72 publications listed at Scopus, with an H-index of 14 (Nov, 2020). Dr Au Yeung was awarded the Health and Medical Research Fund Research Fellowship (2014), and the American Journal of Epidemiology (AJE) Article of the Year (2015). Dr Au Yeung is currently an editorial board member of Scientific Reports.

Selected Publications

(*Denotes corresponding author, † Denotes joint senior author)

  1. Luo S, Clarke S, Ramanan A, Thompson S, Langefeld CD, Grom AA, Schooling CM, Gaunt TR, Au Yeung SL†, Zheng J. Platelet glycoprotein Ib alpha chain as a putative therapeutic target for juvenile idiopathic arthritis: a Mendelian randomization study. Arthritis and Rheumatology. 2020 [epub ahead of print]  [2019 IF: 9.586] (Ranked 3 out of 32 under the category of “Rheumatology”) [pubmed link: https://pubmed.ncbi.nlm.nih.gov/33079445/]
  2. Au Yeung SL*, Schooling CM. Impact of urinary sodium on cardiovascular disease and risk factors: a 2 sample Mendelian randomization study. Clinical Nutrition. 2020. [epub ahead of print] [2019 IF: 6.360] (Ranked 9 out of 89 under the category of “Nutrition and Dietetics) [pubmed link: https://pubmed.ncbi.nlm.nih.gov/33004230/]
  3. Luo S, Schooling CM, Wong ICK, Au Yeung SL*, Evaluating the impact of AMPK activation, a target of metformin, on risk of cardiovascular diseases and cancer in the UK Biobank: a Mendelian randomisation study, Diabetologia. 2020 [epub ahead of print] [2018 IF = 7.113] (Ranked 12 out of 145 under the category of “Endocrinology & Metabolism”) [pubmed link: https://pubmed.ncbi.nlm.nih.gov/32748028/]
  4. Au Yeung SL*, Luo S, Schooling CM. The impact of GDF-15, a biomarker for metformin, on the risk of coronary artery disease, breast and colorectal cancer, and type 2 diabetes and metabolic traits: a Mendelian randomisation study. Diabetologia. 2019. 62: 1638-1646. [2018 IF = 7.113] (Ranked 12 out of 145 under the category of “Endocrinology & Metabolism”) [pubmed link: https://pubmed.ncbi.nlm.nih.gov/31161347]
  5. Au Yeung SL, Lam TH. Unite for a Framework Convention for Alcohol Control. Lancet. 2019. 10183: 1778-1779 [Commentary]. [2018 IF = 59.102] (Ranked 2 out of 160 under the category of “Medicine, General & Internal”) [pubmed link: https://pubmed.ncbi.nlm.nih.gov/30955974]
  6. Luo S, Au Yeung SL, Zhao JV, Burgess S, Schooling CM. The association of genetically predicted testosterone with thromboembolism, heart failure and myocardial infarction: a Mendelian randomization study using UK Biobank. British Medical Journal. 2019. 364: l476. [2018 IF = 27.604] (Ranked 5 out of 160 under the category of “Medicine, General & Internal”) [pubmed link: https://pubmed.ncbi.nlm.nih.gov/30842065]
  7. Au Yeung SL*,Luo S, Schooling CM. The impact of glycated hemoglobin (HbA1c) on cardiovascular disease risk: A Mendelian randomization study using UK Biobank. Diabetes Care. 2018. 41: 1991-1997. [2018 IF = 15.270] (Ranked 4 out of 145 under the category of “Endocrinology & Metabolism”) [pubmed link: https://pubmed.ncbi.nlm.nih.gov/29950300]
  8. Au Yeung SL, Borges MC, Lawlor DA. Association of genetic instrumental variables for lung function on coronary artery disease risk: A 2-sample Mendelian randomization study. Circulation: Genomic and Precision Medicine. 2018. 11: e001952. [2018 IF = 4.897] (Ranked 26 out of 174 under the category of “Genetics & Heredity”) [pubmed link: https://pubmed.ncbi.nlm.nih.gov/29650766]
  9. Au Yeung SL, Jiang C, Long M, Cheng KK, Liu B, Zhang W, Lam TH, Leung GM, Schooling CM. Evaluation of moderate alcohol use with QT interval and heart rate using Mendelian randomization analysis among older Southern Chinese men in the Guangzhou Biobank Cohort Study. American Journal of Epidemiology. 2015 182: 320-327 (Selected as the 2015 Articles of the Year). [2018 IF = 4.473] (Ranked 20 out of 186 under the category of “Public, Environmental & Occupational Health”) [pubmed link: https://pubmed.ncbi.nlm.nih.gov/26153479]
  10. Au Yeung SL, Jiang CQ, Cheng KK, Liu B, Zhang WS, Lam TH, Leung GM, Schooling CM. Is aldehyde dehydrogenase 2 a credible genetic instrument for alcohol use in Mendelian randomization analysis in Southern Chinese men? International Journal of Epidemiology 2013; 42(1): 318-28. [2018 IF = 7.339] (Ranked 6 out of 186 under the category of “Public, Environmental & Occupational Health”) [pubmed link: https://pubmed.ncbi.nlm.nih.gov/23243119]
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