Yen, Hui Ling

YHL
Associate Professor

Division of Public Health Laboratory Sciences

  • BVM(Nat Taiwan), MSc(Nat Taiwan), PhD(Mich)
Biography

Dr. Hui-Ling Yen received her Ph.D. in Epidemiological Science from The University of Michigan, Ann Arbor followed by her postdoctoral training at St. Jude Children’s Research Hospital, Memphis, TN. Her research interests focus on understanding the mechanisms of influenza transmission among and between different reservoirs, investigating potential virus-host interactions that affect viral pathogenicity and transmission, and examining the molecular determinants that confer antiviral resistance.

A major research focus in her lab has been on transmission mechanisms. The ongoing research projects apply interdisciplinary research tools to study the modes of transmission for influenza and other respiratory viruses under laboratory settings and in the field, including at the animal-human interfaces. Her lab also uses genetic analyses, molecular biology, and phenotypic measurements to study critical molecular determinants and their effect on protein functionality and viral fitness. Those studies are in collaboration with local researchers from the University of Hong Kong (Hong Kong), Guangdong Provincial CDC (China), Genomic Research Centre, Academia Sinica (Taiwan), and St. Jude Children’s Research Hospital (USA).

Dr Yen is a full member of the American Society of Virology and a committee member of ISIRV Antiviral Group. She serves at Editorial Boards of Antiviral Research, Indoor Air, and PLOS ONE.

Selected Publications

(#, first author; *, corresponding author)

  1. Xie C#, Lau EHY, Yoshida T, Yu H, Wang X, Wu H, Wei J, Cowling B, Peiris M, Li Y, Yen HL*. Detection of influenza and other respiratory viruses in air sampled from a university campus: a longitudinal study. Clin Infect Dis. 2020;70(5):850-858.[2018 IF = 9.055] (Ranked  3 out of 89 under the category of “Infectious Diseases”) (Citation: 0)
  2. Wu J#, Ke C, Lau EHY, Song Y, Cheng KL, Zou L, Kang M, Song T*, Peiris M, Yen HL*. Influenza H5/H7 virus vaccination in poultry and reduction of zoonotic infections, Guangdong Province, China, 2017-18. Emerg Infect Dis. 2019;25(1):116-118. . [2018 IF = 7.185] (Ranked  5 out of 89 under the category of “Infectious Diseases”) (Citation: 18)
  3. Belser JA#*, Barclay W, Barr I, Fouchier RAM, Matsuyama R, Nishiura H, Peiris M, Russell CJ, Subbarao K, Zhu H, Yen HL*. Ferrets as models for influenza virus transmission studies and pandemic risk assessments. Emerg Infect Dis. 2018 Jun;24(6):965-971. [2018 IF = 7.185] (Ranked  5 out of 89 under the category of “Infectious Diseases”) (Citation: 8)
  4. Zhou J#, Wei J, Choy KT, Sia SF, Rowlands DK, Yu D, Wu CY, Lindsley WG, Cowling BJ, McDevitt J, Peiris M*, Li Y, Yen HL*. Defining the sizes of airborne particles  that mediate influenza transmission in ferrets. Proc Natl Acad Sci USA. 2018. pii: 201716771. [2018 IF = 9.58] (Ranked 7 out of 69 under the category of “Multidisciplinary Sciences”) (Citation: 8)
  5. Teng O#, Chen ST, Hsu TL, Sia SF, Cole S, Valkenburg SA, Hsu TY, Zheng J, Tu W, Bruzzone R, Peiris JSM, Hsieh SL*, Yen HL*. CLEC5A-mediated enhancement of the inflammatory response in myeloid cells contributes to influenza pathogenicity in vivo. J Virol. 2016;91(1). pii: e01813-16. [2018 IF = 4.324] (Ranked 8 out of 36 under the category of “Virology”) (Citation: 9)
  6. Luk GS#, Leung CY, Sia SF, Choy KT, Zhou J, Ho CC, Cheung PP, Lee EF, Wai CK, Li PC, Ip SM, Poon LL, Lindsley WG, Peiris M*, Yen HL*. Transmission of H7N9 Influenza Viruses with a Polymorphism at PB2 Residue 627 in Chickens and Ferrets. J Virol. 2015;89:9939-51. [2018 IF = 4.324] (Ranked 8 out of 36 under the category of “Virology”) (Citation: 8)
  7. Cheung PP#, Watson SJ, Choy KT, Fun Sia S, Wong DD, Poon LL, Kellam P, Guan Y, Peiris JSM*, Yen HL*. 2014. Generation and characterization of influenza A viruses with altered polymerase fidelity. Nat Commun. 2014;5:4794. [2018 IF = 11.878] (Ranked 5 out of 69 under the category of Multidisciplinary Sciences”) (Citation: 47)
  8. Yen HL#, McKimm-Breschkin JL, Choy KT, Wong DD, Cheung PP, Zhou J, Ng IH, Zhu H, Webby RJ, Guan Y, Webster RG*, Peiris JSM*. Resistance to neuraminidase inhibitors conferred by an R292K mutation in a human influenza virus H7N9 isolate can be masked by a mixed R/K viral population. mBio. 2013;4(4). pii: e00396-13. [2018 IF = 6.747] (Ranked 14 out of 133 under the category ofMicrobiology”) (Citation: 54)
  9. Wong DD#, Choy KT, Chan RW, Sia SF, Chiu HP, Cheung PP, Chan MC, Peiris JS*, Yen HL*. Comparable fitness and transmissibility between oseltamivir-resistant pandemic 2009 and seasonal H1N1 influenza viruses with the H275Y neuraminidase mutation. J Virol. 2012;86: 10558–10570.[2018 IF = 4.324] (Ranked 8 out of 36 under the category of “Virology”) (Citation: 23)
  10. Yen HL#, Liang CH, Wu CY, Forrest HL, Ferguson A, Choy KT, Jones J, Wong DD, Cheung PP, Hsu CH, Li OT, Yuen KM, Chan RW, Poon LL, Chan MC, Nicholls JM, Krauss S, Wong CH, Guan Y, Webster RG*, Webby RJ, Peiris M*. Hemagglutinin–neuraminidase balance confers respiratory-droplet transmissibility of the pandemic H1N1 influenza virus in ferrets. Proc Natl Acad Sci USA. 2011;108:14264-14269. [2018 IF = 9.58] (Ranked 7 out of 69 under the category of “Multidisciplinary Sciences”) (Citation: 127)
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