Dr Hui-Ling Yen received her Ph.D. in Epidemiological Science in 2005 from The University of Michigan, Ann Arbor followed by her postdoctoral training at St. Jude Children’s Research Hospital, Memphis, TN. Her research interests focus on understanding the mechanism facilitating the transmission of influenza A virus among and between different reservoirs, exploring the potential virus-host interactions that affect viral pathogenicity and the host clinical outcome, and examining the molecular determinants that confer antiviral resistance.
The ongoing research projects aim to study the modes of influenza transmission in animal models and at the animal-human interface. We continue to study the functionality of viral proteins associated with transmissibility and pathogenicity. Those studies are in collaboration with researchers from the University of Hong Kong (Hong Kong), Guangdong Provincial CDC (China), Genomic Research Centre, Academia Sinica (Taiwan), and St. Jude Children’s Research Hospital (USA).
Dr Yen is a Full Member of the American Society of Virology. She serves as an Editorial Board Member at Antiviral Research and an Academic Editor at PLoS ONE.
Zhou J, Wei J, Choy KT, Sia SF, Rowlands DK, Yu D, Wu CY, Lindsley WG, Cowling BJ, McDevitt J, Peiris M, Li Y, Yen HL. Defining the sizes of airborne particles that mediate influenza transmission in ferrets. Proc Natl Acad Sci U S A. 2018. pii: 201716771.
Teng O, Chen ST, Hsu TL, Sia SF, Cole S, Valkenburg SA, Hsu TY, Zheng J, Tu W, Bruzzone R, Peiris JSM, Hsieh SL, Yen HL. CLEC5A-mediated enhancement of the inflammatory response in myeloid cells contributes to influenza pathogenicity in vivo. J Virol. 2016;91(1). pii: e01813-16.
Zhou J, Zeng X, Huang G, Zou L, Song Y, Gopinath G, Zhang X, Kang M, Lin J, Cowling BJ, Lindsley WG, Ke C, Peiris JSM, Wu J, Yen HL. Isolation of H5N6, H7N9, and H9N2 avian influenza viruses from air sampled at live poultry markets in China, 2014-2015. Eurosurveillance. 2016;21(35).
Luk GS, Leung CY, Sia SF, Choy KT, Zhou J, Ho CC, Cheung PP, Lee EF, Wai CK, Li PC, Ip SM, Poon LL, Lindsley WG, Peiris M, Yen HL. Transmission of H7N9 Influenza Viruses with a Polymorphism at PB2 Residue 627 in Chickens and Ferrets. J Virol. 2015;89:9939-51.
Cheung PP, Watson SJ, Choy KT, Fun Sia S, Wong DD, Poon LL, Kellam P, Guan Y, Peiris JSM, Yen HL. 2014. Generation and characterization of influenza A viruses with altered polymerase fidelity. Nat Commun. 2014;5:4794
Yen HL, Zhou J, Choy KT, Sia SF, Teng O, Ng IH, Fang VJ, Hu Y, Wang W, Cowling BJ, Nicholls JM, Guan Y, Peiris JS. The R292K Mutation That Confers Resistance to Neuraminidase Inhibitors Leads to Competitive Fitness Loss of A/Shanghai/1/2013 (H7N9) Influenza Virus in Ferrets. J Infect Dis. 2014;210:1900-8.
Yen HL, McKimm-Breschkin JL, Choy KT, Wong DD, Cheung PP, Zhou J, Ng IH, Zhu H, Webby RJ, Guan Y, Webster RG, Peiris JSM. Resistance to neuraminidase inhibitors conferred by an R292K mutation in a human influenza virus H7N9 isolate can be masked by a mixed R/K viral population. mBio. 2013;4(4). pii: e00396-13.
Hu Y, Lu S, Song Z, Wang W, Hao P, Li J, Zhang X, Yen HL, Shi B, Li T, Guan W, Xu L, Liu Y, Wang S, Zhang X, Tian D, Zhu Z, He J, Huang K, Chen H, Zheng L, Li X, Ping J, Kang B, Xi X, Zha L, Li Y, Zhang Z, Peiris M, Yuan Z. Association between adverse clinical outcome in human disease caused by novel influenza A H7N9 virus and sustained viral shedding and emergence of antiviral resistance. Lancet. 2013;381:2273-9.
Wong DD, Choy KT, Chan RW, Sia SF, Chiu HP, Cheung PP, Chan MC, Peiris JS, Yen HL. Comparable fitness and transmissibility between oseltamivir-resistant pandemic 2009 and seasonal H1N1 influenza viruses with the H275Y neuraminidase mutation. J Virol. 2012;86: 10558–10570.
Yen HL, Liang CH, Wu CY, Forrest HL, Ferguson A, Choy KT, Jones J, Wong DD, Cheung PP, Hsu CH, Li OT, Yuen KM, Chan RW, Poon LL, Chan MC, Nicholls JM, Krauss S, Wong CH, Guan Y, Webster RG, Webby RJ, Peiris M. Hemagglutinin–neuraminidase balance confers respiratory-droplet transmissibility of the pandemic H1N1 influenza virus in ferrets. Proc Natl Acad Sci U S A. 2011;108:14264-14269.